Canoga Park High serves several communities, including Canoga Park and portions of Winnetka and West Hills.

To the north and south Bell Creek and Arroyo Calabasas (Calabasas Creek) flow around the campus to join on the east side behind the stadium and become the headwaters of the Los Angeles River. The creeks and river were channelized in the 1940s, but still support wildlife.

The High School opened October 4, 1914, as Owensmouth High School, making it the oldest high school in the west San Fernando Valley. It was in a well built Beaux-Arts Neoclassical architectural style, unusual for a small town two years old, but showing the founders civic pride. The school's name was changed in 1931, after the community of Owensmouth changed its name to Canoga Park. Among the school's features are a Coast Redwood Grove planted in 1936 just north of the football field. A classic Greek outdoor theater was part of the School in early years, and rebuilding is being discussed.

The School has an agriculture/environmental/veterinary science magnet program, which was established in 1994. It also has a one and a half acre farm at the school, which commonly houses sheep, pigs, goats, rabbits, and cattle. Canoga Park High School also has an active chapter of the National FFA Organization (more commonly known as FFA).

The Canoga High school colors are green and white and the sports teams are called "The Hunters".